K-Patents Applications in Biochemical and Pharmaceutical Industries
Ascorbic acid: In the manufacture of Vitamin C
K-Patents Process Refractometer measures the concentration of Ascorbic Acid (Vitamin C) in water in the evaporation stage or in the end product. The refractometer provides in-line data to optimize evaporator efficiency and to control the quality of the final product. Typical range is 10-30% ascorbic acid in water.

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Ca-arabonate: In the manufacture of Vitamin B2 (Riboflavin)
K-Patents Process Refractometer provides concentration measurement of Ca-arabonate/water in dissolving tank. K-Patents measurement can improve the production control and ensure that the Ca-arabonate concentration level is constantly the same before it enters the following production step. Typical measurement range is 10-50%.
Ref: Application Note 4.04.01 pdf

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Calcium Lactate
K-Patents Process Refractometer provides the concentration measurement of Calcium lactate in the fermentation process of sugars. The refractometer measures the concentration of calcium lactate in sorbitol manufacturing. The range in the evaporator stage is 15-45%.

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Citric Acid: C3H8O7
K-Patents Process Refractometer provides real-time process control by measuring the concentration of Citric Acid in the evaporator and vacuum crystallizer. The objective is to balance and optimize the process. Typical measurement range is 60-95% in the crystallizer and 45-65% in the end product.
Ref: Application Note 4.05.01 pdf

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Ethanol/Ethyl Alcohol: C2H5OH
K-Patents Process Refractometer provides the concentration measurement of Ethanol and water mixture in the High Performance Liquid Chromatography (HPLC).

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Ethylene Glycol in Cooling Reactor: (C2H5OH)2
K-Patents Process Refractometer provides the concentration measurement of Ethylene Glycol in reactor cooling. The desired concentrations are obtained by mixing a full strength of solution with water. Typical measurement ranges are 0-40% and 30-70%.

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Gelatin
K-Patents Process Refractometer provides measurement of Gelatin in acid process or in liming process. K-Patents PR-01-S measures the Gelatin extract after the filtration and before the evaporation plant. Typical measurement ranges are 0-15% and 10-40%.
Ref: Application Note 4.05.02 pdf

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Glucose blending: In the manufacture of Penicillin and Antibiotics
K-Patents Process Refractometer provides in-line concentration measurement of Glucose in the feed to fermenter to assure the feed glucose concentration is correct. The signal from the output signal can be used to control e.g. the water valve. Typical range is 40-80%.

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Lactic acid, Lactulose
K-Patents Process Refractometer provides concentration measurement of Lactic acid in the manufacture process by fermentation of sugars. The refractometer measures the concentration of lactulose in water e.g. in evaporation and in crystallization to provide better control of the process and better quality of the end product. Typical range is 0-70%.

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Monosodium Glutamate (MSG): C8H8NNaO4 · H2O
K-Patents Process Refractometer provides Brix measurement of Monosodium Glutamate in crystallizer by-pass line. The product is pumped through the heat exchanger continuously. The total density is measured and the outlet of pump starts to take the product out of the crystallizer. At the minimum level the crystallizer is fed with new product to get the supersaturation within tolerances again. Typical measurement range is 45-65 Brix.
Ref: Application Note 4.05.03 pdf

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Urea: NH2CONH2 in the manufacture of Insulin
K-Patents Process Refractometer provides real-time quality control by measuring the concentration of dissolved urea in water in the recirculation loop in the manufacture of Insulin. Typical measurement range is 1.380-1.395 R.I.

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To find out how You can benefit from using a K-Patents Process Refractometer, please contact us or send us an Information request.