K-Patents Applications in Pharmaceuticals and Biochemicals Industry

6.01.00 Pharmaceutical Processing

6.01.01 Vitamin B-2 Production Process
6.01.02 Aspirin Crystallization
6.01.03 Vaccine Production Process
6.01.04 Protein Concentration and Diafiltration

6.02.00 Biochemical Processing

6.02.01 Monosodium Glutamate (MSG) Crystallization
6.02.02 L-Lysine Evaporation Process

 6.03.00 Biopolymer Processing

6.03.01 Wet-Spinning of Alginate Fibers

6.01.00 Pharmaceutical Processing:

Overview of Process Control
Ref. 6.01.00 Pharmaceutical Processing (pdf)

6.01.01 Vitamin B-2 Production Process:

Ca-Arabonate is used to manufacture Vitamin B-2, Riboflavin. Corn is converted into glucose, which is then oxidized and purified by an ion-exchanger into Ca-Arabonate. Ca-Arabonate is precipitated and separated by centrifugation, then dissolved in water before further processing it into Vitamin B-2.
Ref. 6.01.01 Vitamin B-2 Production Process (pdf)

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6.01.02 Aspirin Crystallization:

Aspirin is the most widely sold over-the-counter drug. The production process involves the reaction of Salicylic acid and acetic anhydride in glass lined vessels. The liquid produced is pumped to a crystallizer, where it is cooled down to start the crystallization to Aspirin. The Aspirin is then filtered to remove the acetic acid and solvent, which are recovered and possibly recycled. The crystals are then washed and filtered again. The crystals are sent to sifting, granulating and tableting after drying.
Ref. 6.01.02 Aspirin Crystallization (pdf)

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6.01.03 Vaccine Production Process:

The viral vaccines are either produced by inoculating viruses into specific pathogen-free eggs or in animal cell culture based process. The allantoic fluid of these processes is harvested and purified by centrifugation and stabilised with buffer containing sucrose.
Ref. 6.01.03 Vaccine Production Process (pdf)

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6.01.04 Protein Concentration and Diafiltration:

Diafiltration is a technique using ultrafiltration (UF) membranes to separate the components of solutions and suspensions based on their molecular size, although other factors such as molecular shape and charge can also play a role.

Ref. 6.01.04 Protein Concentration and Diafiltration (pdf)

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6.02.01 Monosodium Glutamate (MSG) Crystallization:

Monosodium glutamate, more commonly referred to as MSG, is a sodium salt (C5H8NNaO4) of the non-essential amino acid glutamic acid. It is used to intensify the natural flavor of meats and vegetables.
Ref. 6.02.01 Monosodium Glutamate (MSG) Crystallization (pdf)

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6.02.02 L-Lysine Evaporation Process:

L-Lysine evaporation process is the process of producing microbially fermented amino acid commonly used for a variety of industrial use, such as feed additive, food material and health supplements. L-Lysine is essential for human and animal nutrition.
Ref. 6.02.02 L-Lysine Evaporation Process (pdf)

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6.03.01 Wet-Spinning of Alginate Fibers:

Fibers made of alginate are very popular in the pharmaceutical applications, especially in the production of wound dressings. These fibers are biocompatible, have hemostatic properties and accelerate the healing process by creating a gel that keeps a moist interface on the surface of the wound. The composition of the fibers can be modified by a controlled process to enhance their hemostatic properties and obtain fibers with additional healing effects.
Ref. 6.03.01 Wet-Spinning of Alginate Fibers (PDF)

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